Initially, this collection consisted mostly of PROTACs, bivalent ligands with a warhead designed to recruit an E3 ligase of the UPS system linked to a warhead designed to bind the target of interest. Rapid expansion of the uses and techniques of this technology have resulted in molecules that recruit other types of proteins to initiate degradation and which use different architectures to accomplish this goal. A continually evolving list of the types of molecules included in this collection, and a brief description of each type, can be found here.

A complete list of the PROTACs and PROTAC-related molecules in BioGRID can be found here or subsets of interest can be found by using the chemical search function on the BioGRID home page with terms such as “PROTAC”, “SNIPER” or “Molecular Glue”.