Bivalent Ligand Types and Descriptions

Type Description
PROTAC Proteolysis Targeting Chimera; structured as E3 binding moiety–linker–target binding moiety; target degraded via UPS
SNIPER Specific and Non-genetic Inhibitor-of-apoptosis proteins (IAPs)-dependent Protein Eraser; structured as IAP ligand–linker–target binding moiety; target degraded via UPS
HaloPROTAC PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety–linker–HaloTag binding moiety; target degraded via UPS
CLIPTAC PROTAC variant formed in cells by click chemistry; structured as E3 binding moiety–linker–target binding moiety; target degraded via UPS
LYTAC Lysosome Targeting Chimera; structured as glycopeptide ligand–linker–target binding moiety; target degraded via endosome-lysosome system
AUTAC/ATTEC Autophagosome Tethering Compound; structured as a LC3 binding moiety–linker–target binding moiety; target degraded via autophagic degradation
Molecular Glue Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex
Opto-PROTAC PROTAC variant in which degradation activity can be regulated by exposure to light; structured as E3 binding moiety–linker–target binding moiety; target degraded via UPS
bioPROTAC Engineered intracellular proteins consisting of a target-binding domain directly fused to an E3 ubiquitin ligase; NOTE: the format for this BVL name is (Target:GFP fusion — E3:GFP binding scaffold fusion)
nano-PROTAC A nano-particle containing a Proteolysis Targeting Chimera; structured as E3 binding moiety–linker–target binding moiety, which is activatable in the presence of a specific stimulus; target degraded via UPS
AbTAC Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS
RIBOTAC Ribonuclease Targeting Chimera; structured as a ribonuclease recruiting moiety-linker-RNA binding moiety
 
bivalent_ligand_types_and_definitions.txt · Last modified: 2023/11/07 16:01 by jenn