| Type | Description |
| PROTAC | Proteolysis Targeting Chimera; structured as E3 binding moiety–linker–target binding moiety; target degraded via UPS |
| SNIPER | Specific and Non-genetic Inhibitor-of-apoptosis proteins (IAPs)-dependent Protein Eraser; structured as IAP ligand–linker–target binding moiety; target degraded via UPS |
| HaloPROTAC | PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety–linker–HaloTag binding moiety; target degraded via UPS |
| CLIPTAC | PROTAC variant formed in cells by click chemistry; structured as E3 binding moiety–linker–target binding moiety; target degraded via UPS |
| LYTAC | Lysosome Targeting Chimera; structured as glycopeptide ligand–linker–target binding moiety; target degraded via endosome-lysosome system |
| AUTAC/ATTEC | Autophagosome Tethering Compound; structured as a LC3 binding moiety–linker–target binding moiety; target degraded via autophagic degradation |
| Molecular Glue | Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex |
| Opto-PROTAC | PROTAC variant in which degradation activity can be regulated by exposure to light; structured as E3 binding moiety–linker–target binding moiety; target degraded via UPS |
| bioPROTAC | Engineered intracellular proteins consisting of a target-binding domain directly fused to an E3 ubiquitin ligase; NOTE: the format for this BVL name is (Target:GFP fusion — E3:GFP binding scaffold fusion) |
| nano-PROTAC | A nano-particle containing a Proteolysis Targeting Chimera; structured as E3 binding moiety–linker–target binding moiety, which is activatable in the presence of a specific stimulus; target degraded via UPS |
| AbTAC | Antibody-based PROTACs, in which bispecific IgGs bind to two proteins simultaneously, an E3 and POI; target degraded via UPS |
| RIBOTAC | Ribonuclease Targeting Chimera; structured as a ribonuclease recruiting moiety-linker-RNA binding moiety |