Chemical curation is undertaken by BioGRID for projects of special interest in an effort to provide more comprehensive datasets in which protein, genetic and chemical interaction data are integrated to support drug development and experimental advancements. These projects of special interest currently include the Ubiquitin Proteasome System (UPS) and COVID relevant chemicals.

• Small Molecule - includes medicines, drugs and chemicals that are made synthetically or purified from plants
• Polypeptidic - this term is used to refer to PROTACs designed to use peptides instead of small molecules as the recruiting warhead moieties of the bivalent ligand.
• Biologic - biologics include medicines and drugs that are generally purified from living culture systems or from blood and can include vaccines, growth factors, immune modulators, antibodies, and other products derived from human blood and plasma. BioGRID includes peptides under this compound type.

Our COVID collection includes small molecules with demonstrated relevance for the viruses SARS-CoV, MERS-CoV or SARS-CoV-2. This data is curated directly from the literature and can include interactions between small molecules and virally encoded protein or RNA targets or interactions between small molecules and relevant host proteins.

These small molecules may have demonstrated inhibitory activity against a target or may be shown to disrupt an interaction between two proteins such as a host receptor to viral spike protein. More detailed information regarding the mechanism of action can be found in the notes section of the protein-chemical interaction.

The UPS chemical collection includes small molecules which modulate the activity of UPS genes (such as E3 or proteasome inhibitors) and an extensive collection of engineered ligands capable of recruiting UPS proteins to initiate degradation of proteins of interest, thus hi-jacking the UPS system to target difficult to drug proteins. More information about these engineered ligands can be found on our PROTAC curation guide.