Experimental Setup Terms

Term	Description
Drug exposure	Organisms or cells are grown in the presence of a CRISPR based gene/genome engineering system while also being subjected to any substance which when absorbed into a living organism may modify one or more of its functions.
Timecourse	Organisms or cells are grown in the presence of a CRISPR based gene/genome engineering system for a specific length of time with no additional selection pressure.
Exposure to different carbon sources	Organisms or cells are grown in the presence of a CRISPR based gene/genome engineering system while also being assayed for ability to use various compounds as carbon sources.
Toxin exposure	Organisms or cells are grown in the presence of a CRISPR based gene/genome engineering system while also being subjected to a poisonous substance produced by a biological organism such as a microbe, animal or plant.
Virus exposure	Organisms or cells are grown in the presence of a CRISPR based gene/genome engineering system while also being subjected to a minute infectious agents whose genomes are composed of DNA or RNA.
Ligand Exposure	Organisms or cells are grown in the presence of a CRISPR based gene/genome engineering system while also being subjected to a molecule known to bind a target protein in the cell likely resulting in modulation of a specific signaling cascade.
T cell exposure	Cells are grown in the presence of a two cell-type (2CT) CRISPR system involving human T cells as effectors and other cell types as targets in order to identify genes essential for the effector function of T cells (EFT).
Implantation to mouse model	Cells are grown in the presence of a CRISPR based gene/genome engineering system and then implanted into a mouse model, generally to ascertain effect on viability or cancer development of the mouse.
Other	Organisms or cells are grown in the presence of a CRISPR based gene/genome engineering system while also being subjected to other conditions, details of which are given in the notes.

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