About BioGRID ORCS

BioGRID ORCS is an open repository of CRISPR screens compiled through comprehensive curation efforts. Our current index is version 1.0.2 and searches more than 43 publications and 58,377 genes to return more than 561 CRISPR screens from 3 major model organism species and 431 cell lines. All screen data are freely provided through our search index and available via download in a wide variety of standardized formats.

Contact Information

BioGRID Team

  • Lorrie Boucher [curator, Toronto]
  • Bobby-Joe Breitkreutz [software engineer, Toronto]
  • Christie Chang [curator, Princeton]
  • Andrew Chatr-Aryamontri [curator, Montreal]
  • Kara Dolinski [co-principal investigator, Princeton]
  • Sonam Dolma [curator, Toronto]
  • Nadine Kolas [curator, Toronto]
  • Genie Leung [curator, Toronto]
  • Lara O’Donnell [curator, Toronto]
  • Rose Oughtred [curator, Princeton]
  • Jennifer Rust [curator, Princeton]
  • Chris Stark [software engineer, Toronto]
  • Mike Tyers [principal investigator, Montreal]
  • Andrew Willems [curator, Toronto]
  • Frederick Zhang [curator, Toronto]

Alumni

  • Ashton Breitkreutz [curator, Toronto]
  • Daici Chen [curator, Montreal]
  • Sven Heinicke [software engineer, Princeton]
  • Jodi Hirschman [curator, Princeton]
  • Michael Livstone [curator, Princeton]
  • Rochelle McAdam [curator, Toronto]
  • Julie Nixon [curator, Edinburgh]
  • Sara Oster [curator, Toronto]
  • Lindsay Ramage [curator, Edinburgh]
  • Teresa Reguly [curator, Toronto]
  • Adnane Sellam [curator, Montreal]
  • Jean Tang [curator, Toronto]
  • Chandra Theesfeld [curator, Princeton]
  • Andrew Winter [curator, Edinburgh]

BioGRID Funding

NIH - #R01 RR024031

BioGRID Publications

  • Oughtred R, Stark C, Breitkreutz BJ, Rust J, Boucher L, Chang C, Kolas N, O'Donnell L, Leung G, McAdam R, Zhang F, Dolma S, Willems A, Coulombe-Huntington J, Chatr-Aryamontri A, Dolinski K, Tyers M. The BioGRID interaction database: 2019 update. Nucleic Acids Res. 2019 Jan 8;47(D1):D529-D541 [ Pubmed, NAR ]
  • Chatr-Aryamontri A, Oughtred R, Boucher L, Rust J, Chang C, Kolas NK, O'Donnell L, Oster S, Theesfeld C, Sellam A, Stark C, Breitkreutz BJ, Dolinski K, Tyers M. The BioGRID interaction database: 2017 update. Nucleic Acids Res. 2016 Dec 14;2017(1) [ Pubmed, NAR ]
  • Oughtred R, Chatr-Aryamontri A, Breitkreutz BJ, Chang CS, Rust JM, Theesfeld CL, Heinicke S, Breitkreutz A, Chen D, Hirschman J, Kolas N, Livstone MS, Nixon J, O'Donnell L, Ramage L, Winter A, Reguly T, Sellam A, Stark C, Boucher L, Dolinski K, Tyers M. Use of the BioGRID Database for Analysis of Yeast Protein and Genetic Interactions. Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.prot088880 [ Pubmed ]
  • Oughtred R, Chatr-Aryamontri A, Breitkreutz BJ, Chang CS, Rust JM, Theesfeld CL, Heinicke S, Breitkreutz A, Chen D, Hirschman J, Kolas N, Livstone MS, Nixon J, O'Donnell L, Ramage L, Winter A, Reguly T, Sellam A, Stark C, Boucher L, Dolinski K, Tyers M. BioGRID: A Resource for Studying Biological Interactions in Yeast. Cold Spring Harb Protoc. 2016 Jan 4;2016(1):pdb.top080754 [ Pubmed ]
  • Wildenhain J, Spitzer M, Dolma S, Jarvik N, White R, Roy M, Griffiths E, Bellows DS, Wright GD, Tyers M. Prediction of Synergism from Chemical-Genetic Interactions by Machine Learning. Cell Systems. Dec. 23, 2015, 1(6):383-95. [ Pubmed ]
  • Chatr-Aryamontri A, Breitkreutz BJ, Oughtred R, Boucher L, Heinicke S, Chen D, Stark C, Breitkreutz A, Kolas N, O'Donnell L, Reguly T, Nixon J, Ramage L, Winter A, Sellam A, Chang C, Hirschman J, Theesfeld C, Rust J, Livstone MS, Dolinski K, Tyers M. The BioGRID interaction database: 2015 update. Nucleic Acids Research. Nov. 2014, [ Pubmed ]
  • Sadowski I, Breitkreutz BJ, Stark C, Su TC, Dahabieh M, Raithatha S, Bernhard W, Oughtred R, Dolinski K, Barreto K, Tyers M. The PhosphoGRID Saccharomyces cerevisiae Protein Phosphorylation Site Database: Version 2.0 Update. Database (Oxford) May 2013; [ Pubmed ]
  • Chatr-Aryamontri A, Breitkreutz BJ, Heinicke S, Boucher L, Winter A, Stark C, Nixon J, Ramage L, Kolas N, O'Donnell L, Reguly T, Breitkreutz A, Sellam A, Chen D, Chang C, Rust JM, Livstone MS, Oughtred R, Dolinski K, Tyers M. The BioGRID Interaction Database: 2013 update. Nucleic Acids Res. 2012 Nov 30. [ Pubmed ]
  • Winter AG, Wildenhain J, Tyers M. BioGRID REST Service, BiogridPlugin2 and BioGRID WebGraph: new tools for access to interaction data at BioGRID. Bioinformatics, 2011 Apr 1. [ Pubmed ]
  • Stark C, Breitkreutz BJ, Chatr-Aryamontri A, Boucher L, Oughtred R, Livstone MS, Nixon J, Van Auken K, Wang X, Shi X, Reguly T, Rust JM, Winter A, Dolinski K, Tyers M. The BioGRID Interaction Database: 2011 update. Nucleic Acids Res. 2010 Nov 11. [ Pubmed ]
  • Breitkreutz A, Choi H, Sharom JR, Boucher L, Neduva V, Larsen B, Lin ZY, Breitkreutz BJ, Stark C, Liu G, Ahn J, Dewar-Darch D, Reguly T, Tang X, Almeida R, Qin ZS, Pawson T, Gingras AC, Nesvizhskii AI, Tyers M. A global protein kinase and phosphatase interaction network in yeast. Science. 2010 May 21;328(5981):1043-6. [ Pubmed ]
  • Stark C, Ting-Cheng Su, Breitkreutz A, Lourenco P, Dahabieh M, Breitkreutz BJ, Tyers M, Sadowski I. PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae. Database. 2010 Jan; Vol. 2010 [ Pubmed ]
  • Salwinski L, Licata L, Winter A, Thorneycroft D, Khadake J, Ceol A, Aryamontri AC, Oughtred R, Livstone M, Boucher L, Botstein D, Dolinski K, Berardini T, Huala E, Tyers M, Eisenberg D, Cesareni G, Hermjakob H. Recurated protein interaction datasets. Nat Methods. 2009 Jan;6(1):39-46. [ Pubmed ]
  • Breitkreutz BJ, Stark C, Reguly T, Boucher L, Breitkreutz A, Livstone M, Oughtred R, Lackner DH, Bähler J, Wood V, Dolinski K, Tyers M. The BioGRID Interaction Database: 2008 update. Nucleic Acids Res. 2008 Jan;36(Database issue):D637-40. Epub 2007 Nov 13. [ Pubmed ]
  • Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hon GC, Myers CL, Parsons A, Friesen H, Oughtred R, Tong A, Stark C, Ho Y, Botstein D, Andrews B, Boone C, Troyanskya OG, Ideker T, Dolinski K, Batada NN, Tyers M. Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. J Biol. 2006;5(4):11. Epub 2006 Jun 8. [ Pubmed ]
  • Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M. BioGRID: a general repository for interaction datasets. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D535-9. [ Pubmed ]
  • Breitkreutz BJ, Stark C, Tyers M. The GRID: the General Repository for Interaction Datasets. Genome Biol. 2003;4(3):R23. Epub 2003 Feb 27. [ Pubmed ]
  • Breitkreutz BJ, Stark C, Tyers M. Osprey: a network visualization system. Genome Biol. 2003;4(3):R23. Epub 2003 Feb 27. [ Pubmed ]

BioGRID Affiliations

 
orcs/aboutus.txt · Last modified: 2019/03/06 18:56 by biogridadmin