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curation_description [2009/12/22 22:23]
curation_description [2017/08/08 12:52]
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-====== BioGRID Curation ====== 
-BioGRID curators capture experimental evidence supporting interactions from the primary literature. Our aim is to curate all interactions in the literature for major model organisms, and selective topic-driven human datasets. Interactions reported in reviews or as unpublished data are not recorded. The BioGRID curation workflow can be viewed {{:​biogrid_workflow.pdf|here}}. 
-BioGRID uses gene identifiers to describe all biological interactors. For each experiment supporting a particular interaction,​ the interacting partners are recorded as a pair of gene identifiers. For physical interaction evidence this means that the article describes an experiment which supports an interaction between a product of the bait gene and a product of the prey (hit) gene. Genetic interaction evidence codes record experiments where the phenotypes of two strains, each having a perturbation of one of the interacting genes, are compared with the phenotype of a strain with both genes perturbed. Self-interactions are recorded, as are reciprocal interactions if the bait-prey directionality is clear. To expedite curation we record interactors,​ experimental evidence codes and pubmed ids but not other potentially useful information such as splice variants, wild type strain background, mutations, specific interaction domains or subcellular localization. ​ 
curation_description.txt · Last modified: 2017/08/08 12:52 (external edit)