BioGRID multi-validated datasets (MV) contain physical interactions that pass a specific set of criteria. This criteria is outlined below:

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A physical interaction with participants A and B with a specific Experimental System and Publication Source is considered multi-validated if:

1. There is another physical interaction in BioGRID where A → B or B → A with the same Publication Source but a different Experimental System
2. There is another physical interaction in BioGRID where A → B or B → A with the same Experimental System but a different Publication Source
3. There is another physical interaction in BioGRID where A → B or B → A with a different Experimental System and a different Publication Source

Genetic interactions are excluded and physical interactions not passing this criteria are excluded. All interactions passing this criteria, including both the querying and the validating interaction are included. Also, the following datasets were combined and treated as one dataset to prevent self-validation.

- Krogan NJ (2004), Krogan NJ (2006), Gavin AC (2006), Collins SR (2007)

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