When searching BioGRID ORCS, you have a number of different options available to help you narrow down exactly what you're searching for. You can select the type of search you want to do, by choosing it from the “dropdown” list in the top right of the search box, as depicted in the image to the right. All searches can be restricted by organism.

BioGRID ORCS Searches are broken down into two categories. Keyword searches and Ontology Term Searches. With keyword searches, you can search by plain text keywords and phrases to return results (search tips, advanced searching). For ontology term searches, you must choose specific ontology terms from a list of options.

There are three main types of keyword searches. By Screen (to search screen annotation), By Protein/Gene (to search protein/gene results) and By Publication (to search for entire publications). Each one can be used to find specific results within the BioGRID ORCS CRISPR Database.

• CAS9 - Search for screens using the enzyme “CAS9”
• Etoposide - Search for screens involving the chemotherapy medication “Etoposide”
• viability - Search for screens with the phenotype “viability”
• MAGeCK - Search for screens using the “Mageck” analysis method
• Gecko - Search for screens using the “Gecko” CRISPR library
• Leukemia - Search for screens in “Leukemia” cell types
• HuH-7 - Search for screens in “HuH-7” cells
• Toxin Exposure - Search for “Toxin Exposure” experiment screens
• Positive Selection - Search for “Positive Selection” screen types