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--- experimental_systems [2018/07/27 16:10]
jenn [Physical Interactions]
+++ experimental_systems [2018/07/27 16:35]
jenn [Genetic Interactions]
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 ===== Genetic Interactions =====
-  *  **Dosage Growth Defect** - A genetic interaction is inferred when over expression or increased dosage of one gene causes a growth defect in a strain that is mutated or deleted for another gene.
+  *  **Dosage Growth Defect** - Overexpression/increased dosage of one gene causes a growth defect in a strain that is mutated/deleted for another gene (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15166139&query_hl=4&itool=pubmed_DocSum|PMID: 15166139]]).
-  *  **Dosage Lethality** - A genetic interaction is inferred when over expression or increased dosage of one gene causes lethality in a strain that is mutated or deleted for another gene.
+  *  **Dosage Lethality** - Overexpression/increased dosage of one gene causes lethality in a strain that is mutated/deleted for another gene (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10805723&query_hl=4&itool=pubmed_DocSum|PMID: 10805723]], Fig. 3).
-  *  **Dosage Rescue** - A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
+  *  **Dosage Rescue** - Overexpression/increased dosage of one gene rescues the lethality or growth defect of a strain mutated/deleted for another gene (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12207708&query_hl=4&itool=pubmed_DocSum|PMID: 12207708]], Fig. 3).
-  *  **Negative Genetic** - Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.
+  *  **Negative Genetic** - Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20093466&query_hl=4&itool=pubmed_DocSum|PMID: 20093466]]).  This term is reserved for high or low throughput studies with scores.
-  *  **Phenotypic Enhancement** - A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
+  *  **Phenotypic Enhancement** - Mutation/deletion/overexpression of one genes results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation/deletion/overexpression of another gene, for example response to DNA damage or transcriptional output (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11890933&query_hl=4&itool=pubmed_DocSum|PMID: 11890933]], Fig. 2).
-  *  **Phenotypic Suppression** - A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
+  *  **Phenotypic Suppression** - Mutation/deletion/overexpression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation/deletion/overexpression of another gene (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10073572&query_hl=4&itool=pubmed_DocSum|PMID: 10073572]]).
-  *  **Positive Genetic** -  Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
+  *  **Positive Genetic** -  Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition.(e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=20093466&query_hl=4&itool=pubmed_DocSum|PMID: 20093466]]).  This term is reserved for high or low throughput studies with scores.
-  *  **Synthetic Growth Defect** - A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
+  *  **Synthetic Growth Defect** - Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a significant growth defect under a given condition (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12871902&query_hl=4&itool=pubmed_DocSum|PMID: 12871902]], Fig. 8).
-  *  **Synthetic Haploinsufficiency** - A genetic interaction is inferred when mutations or deletions in separate genes, at least one of which is hemizygous, cause a minimal phenotype alone but result in lethality when combined in the same cell under a given condition.
+  *  **Synthetic Haploinsufficiency** - A genetic interaction is inferred when mutations or deletions in separate genes, at least one of which is hemizygous, cause a minimal phenotype alone but result in lethality when combined in the same cell under a given condition (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=17167106&query_hl=4&itool=pubmed_DocSum|PMID: 17167106]]).
-  *  **Synthetic Lethality** - A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
+  *  **Synthetic Lethality** - Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in lethality under a given condition (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14690608&query_hl=4&itool=pubmed_DocSum|PMID: 14690608]]).
-  *  **Synthetic Rescue** - A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
+  *  **Synthetic Rescue** - Mutation/deletion of one gene rescues the lethality or growth defect of a strain mutated/deleted for another gene (e.g. [[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14734533&query_hl=4&itool=pubmed_DocSum|PMID: 14734533]], Fig. 1).

Experimental Evidence Codes

Differences