The Biological General Repository for Interaction Datasets (BioGRID) is a database of physical and genetic interactions developed by Mike Tyers' group. It contains high-throughput (HTP) interaction data for Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, and other organisms. For yeast, BioGRID also contains many genetic and protein interactions curated from the primary literature. SGD has incorporated BioGRID's interaction data and will also continue to manually curate yeast interactions. What follows is a description of the BioGRID curation procedure along with some issues and details to keep in mind while curating this information.

The following sections contain detailed information on BioGRID curation guidelines.

• Direction of Interactions (Bait/Hit)
• Biochemical Experimental Systems
• Genetic Experimental Systems
• Modifications
• Qualifications
• Phenotype Curation
• HTP and LTP Interaction Tags
• Submission and Verification

• Should we curate all interactions in a paper?
  • We are capturing all interactions in a paper, even if they are not the main focus of an experiment and have been curated previously. For example, in Fig. 3 of PMID: 15608614, the authors were looking at the effects on the TOM complex after depletion of MIM1. Even if there aren't any interactions being added for MIM1 based on this figure, the interactions between the subunits of the TOM complex (e.g. TOM70, TOM40, etc.) should be added under 'co-purification'.