Interaction data in BioGRID can be accessed via the BioGRID REST service. Interactions in various formats can be fetched from the BioGRID REST Service over HTTP, programmatically or in a browser, at http://biogrid.bio.ed.ac.uk:8080/BiogridRestService/resources/interactions/ This URL will retrieve the first 10,000 interactions in BioGRID, ordered by the BioGRID Interaction Id as found in .tab2 files. Single interactions can be retrieved by appending this URL with a Biogrid Interaction ID (e.g. http://biogrid.bio.ed.ac.uk:8080/BiogridRestService/resources/interactions/103). The results list returned can be filtered by appending ?parameter1=value1& parameter2=value2 etc. to the URL. A full description of possible parameters is given in the table below. A formal description of the REST service, in Web Application Description Language (WADL), can be found at http://biogrid.bio.ed.ac.uk:8080/BiogridRestService/resources/application.wadl. The BioGRID REST service is updated to the latest release of BioGRID on the 2nd of each month and the BioGRID database version being accessed can be determined with the URL: http://biogrid.bio.ed.ac.uk:8080/BiogridRestService/resources/version .

In addition to BioGRID interaction data, interactions from the IMEx databases IntAct, MINT [2] and DIP have been parsed, mapped to BioGRID evidence codes, according to the mapping in LINK, and included as an option for retrieval in the REST service data. The URL parameter “sourceDatabaseList” has a default value of “BioGRID”, but if set to “BioGRID|MINT|INTACT|DIP” the query will retrieve interactions from all databases. Source database origin can be found in the “Source Databases” column of the retrieved data and the “Source Database Identifiers” column (if the parameter format=extendedTab2 is set) allows mapping back to the interaction in the original database. IMEx interaction files are downloaded from their respective websites and integrated into the REST service to coinicide with each monthly BioGRID release. These additional interactions are only available through the BioGRid REST Service and are not currently present in the BioGRID download files.