About the BioGRID
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About the BioGRID
The Biological General Repository for Interaction Datasets (BioGRID) database (http://thebiogrid.org) was developed to house and distribute collections of protein and genetic interactions from major model organism species. BioGRID currently contains over 360,000 interactions from major model organism species, as derived from both high-throughput studies and conventional focused studies. Through comprehensive curation efforts, BioGRID now includes a virtually complete set of interactions reported to date in the primary literature for the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe. A number of new features have been added to the BioGRID including an improved user interface to display interactions based on different attributes, a mirror site and a dedicated interaction management system to coordinate curation across different locations. The BioGRID provides interaction data with monthly updates to Saccharomyces Genome Database, Flybase and Entrez Gene. Source code for the BioGRID and the linked Osprey network visualization system is now freely available without restriction.
Contact Information
- EMAIL: biogridadmin@gmail.com
BioGRID Team
- Lorrie Boucher [curator, Toronto]
- Bobby-Joe Breitkreutz [software engineer, Toronto]
- Andrew Chatr-Aryamontri [curator, Edinburgh]
- Kara Dolinski [co-principal investigator, Princeton]
- Nadine Kolas [curator, Toronto]
- Michael Livstone [curator, Princeton]
- Julie Nixon [curator, Edinburgh]
- Rose Oughtred [curator, Princeton]
- Teresa Reguly [curator, Toronto]
- Jennifer Rust [curator, Princeton]
- Chris Stark [software engineer, Toronto]
- Mike Tyers [principal investigator, Edinburgh]
- Andrew Winter [curator, Edinburgh]
BioGRID Funding
NIH - #R01 RR024031
BioGRID Publications
- Breitkreutz A, Choi H, Sharom JR, Boucher L, Neduva V, Larsen B, Lin ZY, Breitkreutz BJ, Stark C, Liu G, Ahn J, Dewar-Darch D, Reguly T, Tang X, Almeida R, Qin ZS, Pawson T, Gingras AC, Nesvizhskii AI, Tyers M. A global protein kinase and phosphatase interaction network in yeast. Science. 2010 May 21;328(5981):1043-6. [ Pubmed ]
- Stark C, Ting-Cheng Su, Breitkreutz A, Lourenco P, Dahabieh M, Breitkreutz BJ, Tyers M, Sadowski I. PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae. Database. 2010 Jan; Vol. 2010 [ Pubmed ]
- Salwinski L, Licata L, Winter A, Thorneycroft D, Khadake J, Ceol A, Aryamontri AC, Oughtred R, Livstone M, Boucher L, Botstein D, Dolinski K, Berardini T, Huala E, Tyers M, Eisenberg D, Cesareni G, Hermjakob H. Recurated protein interaction datasets. Nat Methods. 2009 Jan;6(1):39-46. [ Pubmed ]
- Breitkreutz BJ, Stark C, Reguly T, Boucher L, Breitkreutz A, Livstone M, Oughtred R, Lackner DH, Bähler J, Wood V, Dolinski K, Tyers M. The BioGRID Interaction Database: 2008 update. Nucleic Acids Res. 2008 Jan;36(Database issue):D637-40. Epub 2007 Nov 13. [ Pubmed ]
- Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hon GC, Myers CL, Parsons A, Friesen H, Oughtred R, Tong A, Stark C, Ho Y, Botstein D, Andrews B, Boone C, Troyanskya OG, Ideker T, Dolinski K, Batada NN, Tyers M. Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. J Biol. 2006;5(4):11. Epub 2006 Jun 8. [ Pubmed ]
- Stark C, Breitkreutz BJ, Reguly T, Boucher L, Breitkreutz A, Tyers M. BioGRID: a general repository for interaction datasets. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D535-9. [ Pubmed ]
- Breitkreutz BJ, Stark C, Tyers M. The GRID: the General Repository for Interaction Datasets. Genome Biol. 2003;4(3):R23. Epub 2003 Feb 27. [ Pubmed ]
- Breitkreutz BJ, Stark C, Tyers M. Osprey: a network visualization system. Genome Biol. 2003;4(3):R23. Epub 2003 Feb 27. [ Pubmed ]
BioGRID Affiliations
