=Ubiquitination background……= =The ubiquitin–proteasome system is a key regulator of most biological processes in eukaryotes, controlling the stability of cell cycle proteins, transcription factors , tumor suppressor proteins, oncoproteins, growth factor receptors. The first step in the degradation of a target protein is the covalent attachment of a chain of ubiquitin by E1 (ubiquitin activating), E2 (ubiquitin conjugating) and E3 (ubiquitin ligase) enzymes. The polyubiquitin chain is recognized by the 26S proteasome, which unfolds the attached protein and degrades it into into short peptides [3]. The specificity of ubiquitin-dependent proteolysis derives from the many hundreds of E3 ubiquitin ligases that recognise particular substrates through dedicated interaction domains. Targeting motifs on substrates are typically short primary sequence elements often referred to as degrons [4].= =The aim of the BioGRID Ubiquitination Project is to capture data on evidence for interactions between proteins involved in or affected by this process from a wide range of the available literature. To provide a resource for researchers in UPS to point to new potential areas of investigation.= The BioGRID database
=Project strategy…= =Literature search= =Curation=
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