====== BioGRID ORCS - REST Service JSON ====== The BioGRID ORCS REST Service JSON format uses the same headers as both the [[orcs:downloads:screen|Screen Format]] and the [[orcs:downloads:screen_index|Screen Index Format]] fields follow the same naming as outlined in those two pages above, with the exception that they are all capitals letters and have spacing replaced with underscores. For example a single entry for the Screen Index may look like the following: { "SCREEN_ID": "17", "SOURCE_ID": "26627737", "SOURCE_TYPE": "pubmed", "AUTHOR": "Hart T (2015)", "SCREEN_NAME": "2-PMID26627737", "SCORES_SIZE": "17648", "FULL_SIZE": "17661", "FULL_SIZE_AVAILABLE": "Yes", "NUMBER_OF_HITS": "1696", "ANALYSIS": "BAGEL", "SIGNIFICANCE_INDICATOR": "Score Significance", "SIGNIFICANCE_CRITERIA": "Score.1 (Bayes Factor) > 15.47", "THROUGHPUT": "High Throughput", "SCREEN_TYPE": "Negative Selection", "SCREEN_FORMAT": "Pool", "EXPERIMENTAL_SETUP": "Timecourse", "DURATION": "18 Days", "CONDITION_NAME": "-", "CONDITION_DOSAGE": "-", "MOI": "~ 0.3", "LIBRARY": "TKO (Toronto Knockout) v1", "LIBRARY_TYPE": "CRISPRn", "METHODOLOGY": "Knockout", "ENZYME": "CAS9", "CELL_LINE": "HeLa", "CELL_TYPE": "Cervical Adenocarcinoma Cell Line", "PHENOTYPE": "viability", "SCORE_COL_COUNT": "1", "SCORE.1_TYPE": "Bayes Factor", "SCORE.2_TYPE": "-", "SCORE.3_TYPE": "-", "SCORE.4_TYPE": "-", "SCORE.5_TYPE": "-", "ORGANISM_ID": "9606", "ORGANISM_OFFICIAL": "Homo sapiens", "NOTES": "Genes with a Bayes Factor (BF) above the threshold of 15.47 at an FDR of 5% (FDR < 0.05) were identified as fitness genes (hits) for this cell line in this CRISPR screen.", "SOURCE": "BioGRID ORCS" } and a single entry in the gene or screen end points might look like the following in JSON { "SCREEN_ID": "370", "IDENTIFIER_ID": "1021", "IDENTIFIER_TYPE": "gene", "OFFICIAL_SYMBOL": "CDK6", "ALIASES": "MCPH12|PLSTIRE", "ORGANISM_ID": "9606", "ORGANISM_OFFICIAL": "Homo sapiens", "SCORE.1": "-1.24882324039", "SCORE.2": "0", "SCORE.3": "-", "SCORE.4": "-", "SCORE.5": "-", "HIT": "YES", "SOURCE": "BioGRID ORCS" } If on the other hand, you are choosing the "tab" option instead of json, the formats will match identically with our primary download formats which you can find here: [[orcs:downloads]]