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orcs:controlled_vocabulary [2019/06/26 11:51]
jenn created
orcs:controlled_vocabulary [2019/06/27 09:02]
jenn
Line 1: Line 1:
-Controlled vocab 1+====== Screen Type Terms ====== 
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 +^  Term  ^ Description ​      ^ 
 +^  Negative Selection ​ | Screen for identifying genes whose perturbation results in cells not surviving the selection mechanism. Typically, the associated phenotype is “viability” or “resistance” and the mutants are underrepresented/​depleted after selection. This fitness screen may be used to determine gene essentiality. May also be referred to as a dropout screen. | 
 +^  Positive Selection ​ | Screen for identifying genes whose perturbation results in cells surviving the selection mechanism, e.g drug exposure. Typically, the associated phenotype is “viability” or “resistance” and the mutants are overrepresented/​enriched after selection. This fitness screen may be used to detect drug resistance and identify drug targets. Also known as an enrichment screen. | 
 +^  Phenotype Screen ​ | Screen for identifying genes whose perturbation results in other non-fitness phenotypes, such as altered nuclear size or detection of a selectable marker for measuring activity of a particular pathway. | 
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 +[[:​orcs:​curation_guide|Back to ORCS Curation Guide]]
 
orcs/controlled_vocabulary.txt · Last modified: 2020/08/19 10:38 by jenn