Screen Type Terms
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- | Controlled vocab 1 | + | ====== Screen Type Terms ====== |
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+ | ^ Term ^ Description ^ | ||
+ | ^ Negative Selection | Screen for identifying genes whose perturbation results in cells not surviving the selection mechanism. Typically, the associated phenotype is “viability” or “resistance” and the mutants are underrepresented/depleted after selection. This fitness screen may be used to determine gene essentiality. May also be referred to as a dropout screen. | | ||
+ | ^ Positive Selection | Screen for identifying genes whose perturbation results in cells surviving the selection mechanism, e.g drug exposure. Typically, the associated phenotype is “viability” or “resistance” and the mutants are overrepresented/enriched after selection. This fitness screen may be used to detect drug resistance and identify drug targets. Also known as an enrichment screen. | | ||
+ | ^ Phenotype Screen | Screen for identifying genes whose perturbation results in other non-fitness phenotypes, such as altered nuclear size or detection of a selectable marker for measuring activity of a particular pathway. | | ||
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+ | [[:orcs:curation_guide|Back to ORCS Curation Guide]] |