====== High Throughput Publications in BioGRID ======


Publications in biogrid with more than 100 interaction evidences are described in the table below. Those which have provided confidence scores or quantifiers for their interactions which have been loaded into BioGRID are indicated in the 'Score' column. For some publications, only a subset of all possible interactions have been loaded, based on a score cut-off suggested by the publication or authors. Where known this cut-off is described in the 'Comments' column.


^Pubmed^Author^Year^Species^HTP Interactions(Raw)^Score^Comments^
|9207794|Fromont-Racine|1997|S.cerevisiae|167 Two-hybrid|No| |
|10688190|Uetz|2000|S.cerevisiae|875 Two-hybrid|No| |
|10900456|Fromont-Racine|2000|S.cerevisiae|266 Two-hybrid|No| |
|11063675|Finger|2000|S.cerevisiae|133 Synthetic Lethality|No| |
|11087867|Newman|2000|S.cerevisiae|177 Two-hybrid|No| |
|11283351|Ito|2001|S.cerevisiae|1585 Two-hybrid|No|As of BioGRID v2.0.29, only interactions with >2 IST hits (Table1) were loaded|
|11387327|Allen|2001|S.cerevisiae|125 Affinity Capture-MS|No| |
|11489916|Drees|2001|S.cerevisiae|205 Two-hybrid|No| |
|11743162|Tong|2002|S.cerevisiae|232 Two-hybrid|No| |
|11743205|Tong|2001|S.cerevisiae|338 Synthetic Lethality|No| |
|11805826|Gavin|2002|S.cerevisiae|3400 Affinity Capture-MS|No| |
|11805837|Ho|2002|S.cerevisiae|3666 Affinity Capture-MS|No| |
|11884590|Ohi|2002|S.cerevisiae|161 Affinity Capture-MS|No| |
|12052880|Sanders|2002|S.cerevisiae|480 Affinity Capture-MS|No| |
|12150911|Grandi|2002|S.cerevisiae|509 Affinity Capture-MS|No| |
|12374754|Nissan|2002|S.cerevisiae|148 Affinity Capture-MS|No| |
|12556496|Lindstrom|2003|S.cerevisiae|109 Affinity Capture-MS|No| |
|12872131|Peng|2003|S.cerevisiae|109 Affinity Capture-MS|No| |
|14574415|Ubersax|2003|S.cerevisiae|369 Biochemical Activity|No| |
|14660704|Graumann|2004|S.cerevisiae|478 Affinity Capture-MS|No| |
|14690591|Hazbun|2003|S.cerevisiae|151 Affinity Capture-MS|No| |
|14690608|Krogan|2003|S.cerevisiae|673 Synthetic Lethality|No| |
|14729968|Krogan|2003|S.cerevisiae|122 Affinity Capture-MS|No| |
|14759368|Krogan|2003|S.cerevisiae|890 Affinity Capture-MS|No| |
|14764870|Tong|2004|S.cerevisiae|3873 Synthetic Lethality|No| |
|15166135|Lesage|2004|S.cerevisiae|191 Synthetic Lethality|No| |
|15292183|Panse|2004|S.cerevisiae|122 Affinity Capture-MS|No| |
|15353583|Krogan|2004|S.cerevisiae|244 Synthetic Lethality|No| |
|15525520|Pan|2004|S.cerevisiae|180 Synthetic Lethality;135 Synthetic Growth Defect|No| |
|15563457|Kong|2005|S.cerevisiae|112 Synthetic Lethality|No| |
|15590687|Hannich|2005|S.cerevisiae|145 Affinity Capture-MS|No| |
|15657441|Ingvarsdottir|2005|S.cerevisiae|94 Synthetic Lethality;46 Affinity Capture-MS|No| |
|15715908|Lesage|2005|S.cerevisiae|305 Synthetic Lethality|No| |
|15725626|Loeillet|2005|S.cerevisiae|127 Synthetic Lethality|No| |
|15741174|Lutzmann|2005|S.cerevisiae|145 Affinity Capture-MS|No| |
|15766533|Zhao|2005|S.cerevisiae|272 Synthetic Lethality;131 Affinity Capture-MS; 84 Two-hybrid|No| |
|15879519|Millson|2005|S.cerevisiae|124 Two-hybrid|No| |
|16093310|Miller|2005|S.cerevisiae|1977 Two-hybrid|No| |
|16118188|Milgrom|2005|S.cerevisiae|107 Synthetic Lethality|No| |
|16155567|Davierwala|2005|S.cerevisiae|564 Synthetic Lethality|No| |
|16157669|Daniel|2006|S.cerevisiae|204 Synthetic Lethality|No| |
|16172405|Measday|2005|S.cerevisiae|42 Synthetic Lethality;175 Synthetic Growth Defect|No| |
|16269340|Schuldiner|2005|S.cerevisiae|5402 Phenotypic Enhancement;1430 Phenotypic Suppression|Yes| |
|16319894|Ptacek|2005|S.cerevisiae|4183 Biochemical Activity|No| |
|16429126|Gavin|2006|S.cerevisiae|7592 Affinity Capture-MS|No| |
|16476776|Frazier|2006|S.cerevisiae|96 Affinity Capture-MS|No| |
|16487579|Pan|2006|S.cerevisiae|1010 Synthetic Lethality;4317 Synthetic Growth Defect|No| |
|16554755|Krogan|2006|S.cerevisiae|7079 Affinity Capture-MS|No| |
|16729061|Ye|2005|S.cerevisiae|111 Synthetic Lethality;179 Synthetic Growth Defect|No| |
|17167106|Haarer|2007|S.cerevisiae|201 Synthetic Haploinsufficiency|No| |
|17200106|Collins|2007|S.cerevisiae|9064 Affinity Capture-MS|Yes|Computationally derived; loaded only those identified as high confidence by author|
|17314980|Collins|2007|S.cerevisiae|11606 Phenotypic Enhancement;2815 Phenotypic Suppression|Yes| |
|17507646|Aronova|2007|S.cerevisiae|102 Co-fractionation|No| |
|17634282|Wong|2007|S.cerevisiae|604 Two-hybrid|No|Only multiple screen hits loaded.|
|17922018|Oeffinger|2007|S.cerevisiae|335 Affinity Capture-MS; 40  Affinity Capture-RNA |No| |
|17923092|McClellan|2007|S.cerevisiae|1414 Synthetic Growth Defect|No|Chemical-Genetic interactions|
|18194531|Schöner|2008|S.cerevisiae|268 Synthetic Lethality|No| |
|18212056|Mitchel|2008|S.cerevisiae|42 Synthetic Lethality;234 Synthetic Growth Defect;34 Affinity Capture-MS  |No| |
|18408161|Decourty|2008|S.cerevisiae|169  Synthetic Growth Defect; 34 Affinity Capture-MS|No| |
|18458063|Fillingham|2008|S.cerevisiae|154  Synthetic Growth Defect|No| |
|18467557|Tarassov|2008|S.cerevisiae|2616 PCA|No| |
|18511909|Dekker |2008|S.cerevisiae|109 Affinity Capture-MS; 70 Synthetic Lethality|No| |
|18627629|Logan|2008|S.cerevisiae|114 Synthetic Lethality; 110  Synthetic Growth Defect|No| |
|18667435|Colomina|2008|S.cerevisiae|317 Protein-RNA|No| |
|18676811|Lin|2008|S.cerevisiae|772 Synthetic Lethality; 1720  Synthetic Growth Defect; 102 Synthetic Rescue|No| | 
|18719252|Yu|2008|S.cerevisiae|1778 Two-hybrid|No| |
|18780730|Sinha|2008|S.cerevisiae|988 Synthetic Growth Defect|No| |
|18805955|Hasegawa|2008|S.cerevisiae|1092 Affinity Capture-RNA|No| |
|18845848|Addinall|2008|S.cerevisiae|20 Synthetic Lethality; 126  Synthetic Growth Defect; 240 Synthetic Rescue|No| |
|19061648|Wilmes|2008|S.cerevisiae|3803 Phenotypic Enhancement;2655 Phenotypic Suppression|Yes| |
|19269370|Fiedler|2009|S.cerevisiae|2642 Phenotypic Enhancement;1409 Phenotypic Suppression|Yes| |
|19536198|Gong|2009|S.cerevisiae|1420 Affinity Capture-MS|Yes|The authors note that 21,687 interactions were identified as high confidence based on experimental scores and the distribution of scores in reference databases.  Only 1420 high confidence interactions were submitted to BioGRID by the authors because they met the additional criteria of containing reciprocal interactors in terms of the bait-prey relationship. |
|18818364|Roguev|2008|S.pombe|5769 Phenotypic Enhancement;1811 Phenotypic Suppression|Yes| |
|18931302|Dixon|2008|S.pombe|670 Synthetic Growth Defect|No| |
|14704431|Li|2004|C.elegans|4422 Two-hybrid|No|Core and non-core interactions loaded|
|16845399|Lehner|2006|C.elegans|336 Phenotypic Enhancement|No| RNAi knock down combined with mutation|
|17417969|Ceron|2007|C.elegans|518 Phenotypic Enhancement|No| RNAi knock down combined with mutation|
|17897480|Byrne|2007|C.elegans|1251 Phenotypic Enhancement|No| RNAi knock down combined with mutation|
|8722784|Karim|1996|D.melanogaster|53 Phenotypic Enhancement; 50 Phenotypic Suppression|No| |
|9883586|Maixner|1998|D.melanogaster|9 Phenotypic Enhancement; 128 Phenotypic Suppression|No| |
|11901120|Peña-Rangel|2002|D.melanogaster|97 Phenotypic Enhancement; 40 Phenotypic Suppression|No| |
|14605208|Giot|2003|D.melanogaster|20193 Two-hybrid|No| |
|15575970|Stanyon|2004|D.melanogaster|1769 Two-hybrid|No| |
|12795696|Risseeuw|2003|A.thaliana|128 Two-hybrid|No| |
|15781858|Hackbusch|2005|A.thaliana|177 Two-hybrid|No| |
|15805477|de Folter|2005|A.thaliana|263 Two-hybrid|No| |
|18642946|Dortay|2008|A.thaliana|156 Two-hybrid|No| |
|12614612|Kneissl|2003|H.sapiens|149 Two-hybrid; 13 Affinity Capture-Western |No| |
|14743216|Bouwmeester|2004|H.sapiens|115 Affinity Capture-MS |No|Only interactions described as high confidence by author were loaded|
|15175163|Sato|2004|H.sapiens|250 Affinity Capture-MS |No| |
|15231747|Lehner|2004|H.sapiens|129 Two-hybrid |No| |
|15761153|Barrios-Rodiles|2005|H.sapiens|393 Affinity Capture-Luminescence|No|All interactions with LIR >3 from Table S2 were loaded|
|16169070|Stelzl|2005|H.sapiens|2527 Two-hybrid |No|Interactions described by author as Medium and High quality were loaded|
|16189514|Rual|2005|H.sapiens|2744 Two-hybrid; 111 Affinity Capture-Western|No| |
|17353931|Ewing|2007|H.sapiens|2068 Two-hybrid|Yes| |
|18782753|Goudreault|2009|H.sapiens|288 Affinity Capture-MS ; 20 Affinity Capture-Western|No| |
|19690564|van Wijk|2009|H.sapiens|346 Two-hybrid|No|LL set identified by authors as high confidence|
|19549727|Markson|2009|H.sapiens|557 Two-hybrid|Yes|Interactions with scores 4 and 5 identified by authors as high confidence|
|20098747|Fenner|2010|H.sapiens|108 Reconstituted Complex; 6 Two-hybrid; 6 Affinity Capture-Western|No| |