======The CORE Database======
The BioGRID **CORE** is the largest component of the BioGRID architecture in terms of size and volume of data stored. It consistes of 26 tables that contain more than 74 million records. Our primary annotation information is stored and maintained in the **CORE** and is updated frequently from a large number of public resources including [[http://www.ncbi.nlm.nih.gov/gene|Entrez-Gene]], [[http://www.uniprot.org/|UniprotKB]], [[http://flybase.org/|FlyBase]], [[http://www.yeastgenome.org/|SGD]], [[http://www.wormbase.org/|WormBase]], [[http://www.informatics.jax.org/|MGD]], [[http://www.ncbi.nlm.nih.gov/omim/|OMIM]], [[http://uswest.ensembl.org/index.html|Ensembl]], [[http://www.psidev.info/|PSI]], [[http://zfin.org/cgi-bin/webdriver?MIval=aa-ZDB_home.apg|ZFIN]], [[http://www.hprd.org/|HPRD]], [[http://www.arabidopsis.org/|TAIR]], [[http://ecocyc.org/|EcoCYC]], [[http://pubchem.ncbi.nlm.nih.gov/|PubCHEM]], [[http://www.ncbi.nlm.nih.gov/pubmed/|Pubmed]], [[http://www.geneontology.org/|Gene Ontology]], and more. The **CORE** is the foundation of our web-based interfaces and contains the data used for the primary quality control of our annotation. The BioGRID **CORE** tracks additions and deprecations of annotation data and acts as the main conduit between the **[[interaction_management_system|IMS]]** and the **[[web|WEB]]**, which both utilize the **CORE** in their functionality.