====== Bivalent Ligand Types and Descriptions ======
^  Type  ^ Description       ^
^  PROTAC  | Proteolysis Targeting Chimera; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS |
^  SNIPER  | Specific and Non-genetic Inhibitor-of-apoptosis proteins (IAPs)-dependent Protein Eraser; structured as IAP ligand--linker--target binding moiety; target degraded via UPS |
^  HaloPROTAC  | PROTAC variant that induces degradation of HaloTag fusion proteins; structured as E3 binding moiety--linker--HaloTag binding moiety; target degraded via UPS |
^  CLIPTAC  | PROTAC variant formed in cells by click chemistry; structured as E3 binding moiety--linker--target binding moiety; target degraded via UPS |
^  LYTAC  | Lysosome Targeting Chimera; structured as glycopeptide ligand--linker--target binding moiety; target degraded via endosome-lysosome system |
^  AUTAC/ATTEC  | Autophagosome Tethering Compound; structured as an LC3 binding moiety or cGMP-based degradation tag–linker–target binding moiety; target degraded via autophagic degradation |
^  Molecular Glue  | Single chemical moiety that contacts both the E3 and the target in a ternary complex; structured as a single chemical entity without linkers; target degraded via UPS or otherwise inactivated in the ternary complex |
^  opto-PROTAC  | PROTAC variant in which a light-inducible degradation tag can be used to regulate target degradation activity; structured as E3 binding moiety with a photolabile caging group--linker--target binding moiety; target degraded via UPS |
^  bioPROTAC  | Engineered intracellular proteins consisting of a target-binding domain directly fused to an E3 ubiquitin ligase; target degraded via UPS |
^  nano-PROTAC  | Proteolysis Targeting Chimera with a nano-particle based delivery system, allowing for enhanced delivery targeting; structured as E3 binding moiety--linker--target binding moiety, which is activatable in the presence of a specific stimulus; target degraded via UPS |
^  AbTAC  | Antibody-based PROTACs, in which bispecific antibodies bind to two proteins simultaneously, typically a transmembrane E3 and POI; target usually degraded via lysosomal system |
^  RIBOTAC  | Ribonuclease Targeting Chimera for targeted RNA degradation; structured as a ribonuclease recruiting moiety--linker--RNA binding moiety |
^  DUBTAC  | Deubiquitinase Targeting Chimera; structured as DUB binding moiety--linker--target binding moiety; target deubiquitinated via recruited deubiquitinase (DUB) |